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Phase 1a: 65 healthy adults received CB4211 with no serious adverse events

It is liberated from dietary proteins in the stomach and then it will bind to protective proteins and subsequently to intrinsic factor (IF), a protein primarily secreted by the pancreas in the dog

Store the sealed vial in a consistent location away from the door where temperature fluctuates

188,189 Testing both serum total B 12 levels and levels of indicators of B 12 function such as methylmalonic acid, folate, and homocysteineall of which increase with B 12 deficiencymay also improve detection of deficiency

Nonmigrated cells were removed with cotton swabs, and migrated cells were fixed with ice-cold methanol and stained with 4,6-diamidino-2-phenylindole (DAPI)